Multipole solution of hydrodynamics and higher order harmonics

The time evolution of the medium created in heavy ion collisions can be described by hydrodynamical models. After expansion and cooling, the hadrons are created in a freeze-out. Their distribution describes the final state of this medium. In particular their azimuthal asymmetry, characterized by the elliptic flow coefficient $v_2$, is one of the most important observables in heavy ion physics. In recent years it has been revealed that if measuring relative to higher order event planes $\Psi_n$, higher order flow coefficients $v_n$ for $n>2$ can be measured. This is due to initial state fluctuations, previously not described by analytic solutions of relativistic hydrodynamics. In this paper we show the first solutions that utilize higher order asymmetries and thus yield realistic $v_n$ flow coefficients. It is a clear consequence of this that different flow patterns may lead to the same observed flow coefficients. We also compare our results to PHENIX measurements and determine a possible parameter set corresponding to these data.Comment: 7 pages, 6 figures, accepted in Phys. Rev.

Civil Society in the 'Visegrad Four': Data and Literature in the Czech Republic, Hungary, Poland and Slovakia

The first of three publications on the '25 Years After -- Mapping Civil Society in the Visegrád Four' project contains an overview of existing data and literature in the Czech Republic, Hungary, Poland and Slovakia. It looks at where and what kind of research on civil society has been and is being done, who is doing it and where the gaps are.To be consistent and comparable, the four country reports include the same core sections: relevant publications on civil society in the respective country; existing databases and other data sources; active centres of research, training, and policy studies. More than providing just a list, this report looks at how they can be evaluated in terms of scope, accurateness and depth. Finally, it considers the question of what the most crucial gaps in research and funding in the countries are.An academic volume is slated for the end of 2014. For other publications in English and German, see www.maecenata.eu

Politischer Protest und Mobilisierung von Bürgern im Spiegel der Presse in der Slowakei, Slowenien und Ungarn 1993

'Politischer Protest wird in den postkommunistischen Systemen manchmal als ein Destabilisierungsfaktor für Demokratie und Marktwirtschaft angesehen. Obwohl es mit Sicherheit auch antidemokratische und gegen die Marktwirtschaft gerichtete Protestbewegungen gibt, ist 'Protestkultur' - mit friedlicher Artikulation der Ansprüche einer Zivilgesellschaft - ein wichtiges Element der Bürgerpartizipation und der demokratischen politischen Kultur in Ostmitteleuropa. In der Kommunikationsforschung konnten die im Westen entwickelten Methoden der Untersuchung von Protestereignissen anhand von Presseberichten nicht angewendet werden, da sich keine freie Presse entfalten konnte. Die sozialistischen Systeme manipulierten die Presse und die Massenmedien; über politische Proteste zu berichten war für Journalisten ein Tabu. Erst seit 1989 entstand in den postkommunistischen Ländern eine neue Prostestkultur, und in der neuen Medienlandschaft wurde jetzt über die neuen Konflikte und Protestformen berichtet. Die anhand jeweils einer ungarischen, slowakischen und slowenischen Tageszeitung sowie einer Wochenzeitung für das Jahr 1993 vorgenommene Untersuchung dokumentiert alle Protestereignisse in den drei Ländern, über die berichtet wurde. Unter den vielfältigen Aspekten der Datenbank sind hier Dauer, Teilnehmerzahl, die Relation zur Bevölkerungszahl und die Organisation der Proteste analysiert und eine Typologie der Länder anhand der politischen Rahmenbedingungen und der Protestkultur entwickelt worden.' (Autorenreferat)'In post-Communist systems, political protest is sometimes viewed as a destabilizing factor for democracy and the market economy. Although some protest movements are undoubtedly directed against democracy and the market economy, the 'culture of protest' is in itself - with its peaceful articulation of a civil society's demands - a vital factor in encouraging citizen action and promoting democratic political culture in central and eastern Europe. In order to study protest movements, studies of former Communist society were unable to apply research methods developed in the West that were based on an examination of press reports, since no free press had been allowed to develop. Socialist systems manipulated the press and mass media. Any reporting on political protests by journalists was taboo. Only in 1989 did a new protest culture begin to emerge in post-Communist countries, and only then did the new media landscape begin to report on these new forms of conflict and protest. The present report has taken one daily newspaper each from Hungary, Slovakia and Slovenia for 1993 and documented all reports on protests which took place in these three countries during that time. From among the various databank entries available, the report analyses data on the duration, number of participants, percentage of overall population, and the organization of protests. A typology for each country has also been developed to define its respective protest culture and political framework.' (author's abstract

Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study

Background The anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations of this brain area have been found in migraine. In addition, altered serotonergic neurotransmission has been repeatedly implicated in the pathophysiology of migraine, although the exact mechanism is not known. Thus, our aim was to investigate the relationship between acute increase of brain serotonin (5-HT) level and the activation changes of the ACC using pharmacological challenge MRI (phMRI) in migraine patients and healthy controls. Methods Twenty-seven pain-free healthy controls and six migraine without aura patients participated in the study. All participant attended to two phMRI sessions during which intravenous citalopram, a selective serotonin reuptake inhibitor (SSRI), or placebo (normal saline) was administered. We used region of interest analysis of ACC to compere the citalopram evoked activation changes of this area between patients and healthy participants. Results Significant difference in ACC activation was found between control and patient groups in the right pregenual ACC (pgACC) during and after citalopram infusion compared to placebo. The extracted time-series showed that pgACC activation increased in migraine patients compared to controls, especially in the first 8-10 min of citalopram infusion. Conclusions Our results demonstrate that a small increase in 5-HT levels can lead to increased phMRI signal in the pregenual part of the ACC that is involved in processing emotional aspects of pain. This increased sensitivity of the pgACC to increased 5-HT in migraine may contribute to recurring headache attacks and increased stress-sensitivity in migraine

Refined heart failure detection algorithm for improved clinical reliability of OptiVol alerts in CRT-D recipients

   Background: The reliability of intrathoracic impedance monitoring for prediction of heart failure (HF) by implantable cardiac devices is controversial. Despite using additional device-based parameters described in the PARTNERS HF study, such as new onset of arrhythmias, abnormal autonomics, low biventricular pacing rate or patient activity level, the predictive power of device diagnostic algorithm is still in doubt. The objective of this study was to compare the device diagnostic algorithm described in the PARTNERS HF study to a newly developed algorithm applying refined diagnostic criteria. Methods: Fourty two patients were prospectively enrolled who had been implanted with an intrathoracic impedance and remote monitoring capable implantable cardiac defibrillator with a cardiac resychroniza­tion therapy (CRT-D) device in this observational study. If a remote OptiVolTM alert occurred, patients were checked for presence of HF symptoms. A new algorithm was derived from the original PARTNERS HF criteria, considering more sensitive cut-offs and changes of patterns of the device-based parameters. Results: During an average follow-up of 38 months, 722 remote transmissions were received. From the total of 128 transmissions with OptiVol alerts, 32 (25%) corresponded to true HF events. Upon multivariate discriminant analysis, low patient activity, high nocturnal heart rate, and low CRT pacing (< 90%) proved to be independent predictors of true HF events (all p < 0.01). Incorporating these three refined criteria in a new algorithm, the diagnostic yield of OptiVol was improved by increasing specific­ity from 37.5% to 86.5%, positive predictive value from 34.1% to 69.8% and area under the curve from 0.787 to 0.922 (p < 0.01), without a relevant loss in sensitivity (96.9% vs. 93.8%). Conclusions: A refined device diagnostic algorithm based on the parameters of low activity level, high nocturnal heart rate, and suboptimal biventricular pacing might improve the clinical reliability of OptiVol alerts.  

Deformability Tests of Pure Niobium

research team at the University of Miskolc's Faculty of Materials Science and Technology has signed a cooperation agreement with the Geneva-based European Organization for Nuclear Research (CERN) for testing of the materials employed in the Crab Cavities will be installed in the next generation of the LHC (the so-called High Luminosity Large Hadron Collider – HL-LHC). At the University of Miskolc, high purity niobium rolling experiments were carried out in conventional (unidirectional) and cross-rolled manners in order to increase the deep drawability of the final sheet. The deformability of niobium was measured by Watts- Ford and compression tests. The microstructure and anisotropy (texture) results of the initial material and the straight-rolled products are reported

Human Plasmacytoid and Monocyte-Derived Dendritic Cells Display Distinct Metabolic Profile Upon RIG-I Activation

Recent advances reveal that metabolic reprogramming is required for adequate antiviral responses of dendritic cells (DCs) that possess the capacity to initiate innate and adaptive immune responses. Several reports indicate that Toll-like receptor (TLR) stimulation of DCs is accompanied by a rapid induction of glycolysis; however, the metabolic requirements of retinoic-acid inducible gene I (RIG-I)-like receptor (RLR) activation have not defined either in conventional DCs (cDCs) or in plasmacytoid DCs (pDCs) that are the major producers of type I interferons (IFN) upon viral infections. To sense viruses and trigger an early type I IFN response, pDCs rely on endosomal TLRs, whereas cDCs employ cytosolic RIG-I, which is constitutively present in their cytoplasm. We previously found that RIG-I is upregulated in pDCs upon endosomal TLR activation and contributes to the late phase of type I IFN responses. Here we report that TLR9-driven activation of human pDCs leads to a metabolic transition to glycolysis supporting the production of type I IFNs, whereas RIG-I-mediated antiviral responses of pDCs do not require glycolysis and rather rely on oxidative phosphorylation (OXPHOS) activity. In particular, TLR9-activated pDCs show increased extracellular acidification rate (ECAR), lactate production, and upregulation of key glycolytic genes indicating an elevation in glycolytic flux. Furthermore, administration of 2-deoxy-D-glucose (2-DG), an inhibitor of glycolysis, significantly impairs the TLR9-induced secretion of type I IFNs by human pDCs. In contrast, RIG-I stimulation of pDCs does not result in any alterations of ECAR, and type I IFN production is not inhibited but rather promoted by 2-DG treatment. Moreover, pDCs activated via TLR9 but not RIG-I in the presence of 2-DG are impaired in their capacity to prime allogeneic naïve CD8+ T cell proliferation. Interestingly, human monocyte-derived DCs (moDC) triggered via RIG-I show a commitment to glycolysis to promote type I IFN production and T cell priming in contrast to pDCs. Our findings reveal for the first time, that pDCs display a unique metabolic profile; TLR9-driven but not RIG-I-mediated activation of pDCs requires glycolytic reprogramming. Nevertheless, the metabolic signature of RIG-I-stimulated moDCs is characterized by glycolysis suggesting that RIG-I-induced metabolic alterations are rather cell type-specific and not receptor-specific

Decreased Openness to Experience Is Associated with Migraine-Type Headaches in Subjects with Lifetime Depression

IntroductionMigraine and depression frequently occur as comorbid conditions, and it has been hypothesized that migraine with and without depression may have a different genetic background. A distinct personality trait constellation has been described in migraineurs. Less attention, however, was paid to personality differences in migraineurs with and without depression which may also shed light on differences in the neurobiological, background. The aim of our study was to investigate big five personality traits, headaches, and lifetime depression (DEP) in a large European general population sample.MethodsRelationship between DEP, Big Five Inventory personality traits, and headaches identified by the ID-Migraine Questionnaire were investigated in 3,026 individuals from Budapest and Manchester with multivariate and logistic regression analyses.ResultsBoth DEP and migraine(ID) showed differences in personality traits. Neuroticism was an independent risk factor for both conditions while a significant interaction effect appeared between the two in the case of openness. Namely, subjects with migraine(ID) and without DEP scored higher on openness compared to those who had depression.ConclusionWhile we confirmed previous results that high neuroticism is a risk factor for both depression and migraine, openness to experience was significantly lower in the co-occurrence of migraine and depression. Our results suggest that increased openness, possibly manifested in optimal or advantageous cognitive processing of pain experience in migraine may decrease the risk of co-occurrence of depression and migraine and thus may provide valuable insight for newer prevention and intervention approaches in the treatment of these conditions

Anatomically heterogeneous populations of CB cannabinoid receptor-expressing interneurons in the CA3 region of the hippocampus show homogeneous input-output characteristics

A subpopulation of GABAergic cells in cortical structures expresses CB1 cannabinoid receptors (CB1 ) on their axon terminals. To understand the function of these interneurons in information processing, it is necessary to uncover how they are embedded into neuronal circuits. Therefore, the proportion of GABAergic terminals expressing CB1 and the morphological and electrophysiological properties of CB1 -immunoreactive interneurons should be revealed. We investigated the ratio and the origin of CB1 -expressing inhibitory boutons in the CA3 region of the hippocampus. Using immunocytochemical techniques, we estimated that approximately 40% of GABAergic axon terminals in different layers of CA3 also expressed CB1 . To identify the inhibitory cell types expressing CB1 in this region, we recorded and intracellularly labeled interneurons in hippocampal slices. CB1 -expressing interneurons showed distinct axonal arborization, and were classified as basket cells, mossy-fiber-associated cells, dendritic-layer-innervating cells or perforant-path-associated cells. In each morphological category, a substantial variability in axonal projection was observed. In contrast to the diverse morphology, the active and passive membrane properties were found to be rather similar. Using paired recordings, we found that pyramidal cells displayed large and fast unitary postsynaptic currents in response to activating basket and mossy-fiber-associated cells, while they showed slower and smaller synaptic events in pairs originating from interneurons that innervate the dendritic layer, which may be due to dendritic filtering. In addition, CB1 activation significantly reduced the amplitude of the postsynaptic currents in each cell pair tested. Our data suggest that CB1 -expressing interneurons with different axonal projections have comparable physiological characteristics, contributing to a similar proportion of GABAergic inputs along the somato-dendritic axis of CA3 pyramidal cells. (c) 2014 Wiley Periodicals, Inc